Irene Santiago

Known For

One Tree Hill

One Tree Hill

Will Trent

Dumb and Dumber

Secrets and Lies

High School Musical

The Reason

The Way of the Gun

All Movies (23)

• Broken Church2025 · as Annie Parker
• Emotions of a Murder2024
• The Penthouse2021 · as Detective Cruz
• The Reason2020 · as Dr. Kelly Collins
• Dear Younger Me2020 · as Karen
• 8 Slices2020 · as Guillermo's Wife
• Assassinaut2019 · as The President of Earth
• Nearly Married2016 · as Nancy Hogan
• Providence2016 · as Edith
• Badge of Faith2015 · as Susan
• Operator2015 · as 911 Caller (uncredited)
• What Would You Do for Love2013 · as Reporter
• Forever Strong2008 · as Reporter
• Minutemen2008 · as News Reporter
• High School Musical2006 · as Chem Teacher
• Charly2002 · as Felicia
• Someone Was Watching2002 · as Carol Sweeney
• Hounded2001 · as Adele
• The Way of the Gun2000 · as Sloppy Prostitute
• I.Q. Dudettes2000 · as Judy
• A Kid Called Danger1999 · as Realtor
• Dumb and Dumber1994 · as Flight Personnel (uncredited)
• Ascendant— · as Estelle

All TV Shows (4)

• Will Trent2023 · as Teacher
• Secrets and Lies2015 · as Lab Tech
• One Tree Hill2003 · as Customer #2
• One Tree Hill2003 · as Nurse